The FA Cup returns this week, with just four non-Premier League clubs left in the competition and most of the current top six still in the tournament.
Championship club Barnsley will play Chelsea for the second time this campaign, previously losing 6-0 to the Blues in the Carabao Cup third round.
The match will be played at Oakwell this time around, with the second tier side looking to take their second chance at causing a major upset.
Swansea also have the difficult task of beating Manchester City, who have won their last fourteen games and only conceded four times in that run.
Steve Cooper’s side have only lost five times this season themselves, and currently sit just two points off of top spot in the Championship.
City’s rivals, Manchester United, have a slightly harder tie at home to West Ham.
United are fresh off the back of a thrilling 3-3 draw against Everton at the weekend, while the Hammers took part in a less entertaining 0-0 stalemate with Fulham.
Fellow title challengers Leicester City are in action too, hosting Brighton on Wednesday night.
In another all-Premier League tie, Everton and Spurs face off looking to advance to the quarter finals.
Both clubs have a good chance of making it far in the competition, but Jose Mourinho and his Spurs side have looked more comfortable with a 5-0 win against AFC Marine and a 4-1 victory away at Wycombe.
Similarly, Wolves and Southampton play against each other on Thursday.
Both sides look unbothered in mid-table in the league, so will be wanting to put together a cup run to light up their season.
After ending Crawley’s fairy tale run in the last round, Bournemouth have the chance to make it to the quarter-finals when they play against Premier League strugglers Burnley.
The Cherries are without a manager after sacking Jason Tindall, with Jonathan Woodgate taking interim charge as they look to correct their run of just four wins in their last 11 games.
Bristol City also come up against a relegation-threatened side in Sheffield United.
The Blades have had a change in form recently, including comfortable cup wins against lower-league opposition such as the Robins’ major rivals Bristol Rovers.
The draw for the quarter finals will take place before the Chelsea match on Thursday evening, with ties expected to be played the weekend beginning March 20.