The Premier League is finally back again after the third international break of the season, with teams returning to action after two weeks off.
Table-toppers Chelsea take on Leicester City in a repeat of last season’s FA Cup final tie, with the Blues hoping to have a better result this time out.
Thomas Tuchel’s side have conceded just four goals all season and lost just one league match, while the Foxes have struggled and find themselves in the bottom half of the table.
Second placed Manchester City will be looking to capitalise on any points dropped by their title rivals when they face Everton.
City have been fantastic this season, while the Toffees started well but have begun to slow down under Rafa Benitez.
In one of the most exciting fixtures this weekend, fourth placed Liverpool go head-to-head with fifth place Arsenal.
The Gunners are unbeaten in their last 10 games, and could go above the Reds and into the top four if they get a result on Saturday.
West Ham have shown no sign of slowing down this season, currently sitting third in the league as well as top of their Europa League group.
A game against Wolves awaits this weekend, in what will be a tough test for the Hammers, with their opponents on a run of three wins from their last five matches.
In fifth place, Manchester United find themselves with just one win from their last five domestic games, which they will need to change in order to push back into the top four.
They take on the newly-promoted Watford, who have also won just once in their last five and currently sit just two points above the relegation zone.
Elsewhere, seventh placed Brighton take on a new-look Aston Villa, who appointed Steven Gerrard as their manager earlier this week.
The Seagulls won’t know what to expect from Villa, who are on a five-game losing streak which ultimately resulted in Dean Smith’s sacking.
Smith didn’t have to wait long to get a new job, taking over at Norwich city just a week after his dismissal.
His first game in charge of the Canaries will be against Southampton on Saturday afternoon.
Tottenham Hotspur welcome Leeds United on Sunday, as they look to continue developing under new manager Antonio Conte.
The former Chelsea boss is yet to lose as manager of Spurs, but will have a tough test against Marcelo Bielsa’s side.
Another new manager will take charge of his first game this weekend, with Eddie howe taking the reins at Newcastle United ahead of their game against Brentford.
The Magpies are the only team in the division without a win this season and they will need to turn things around soon if they are to stand a chance of staying up.
Finally, 18th placed Burnley host Crystal Palace, looking for their second win of the campaign.
Three points would see them rise above Watford and out of the relegation zone.